In vitro and in vivo effects of reovirus on HPV16-transformed mice cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6230" target="_blank" >RIV/00064203:_____/10:6230 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/10:6230 RIV/00023736:_____/10:00008655
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
In vitro and in vivo effects of reovirus on HPV16-transformed mice cells
Original language description
Oncolytic viruses are examined as anticancer therapeutics. In presented experiments we have employed two HPV16-transformed mouse cell lines, TC-1 and MK16, and reovirus type 3, strain Dearing (RV). Both lines are susceptible to RV and produce infectiousvirus in vitro while normal human cells are not susceptible to RV. TC-1 cells produced lesser amounts of virus, but died more rapidly than MK16. When inoculating high doses of infected cells into syngeneic animals their oncogenic activity was suppressedin the case of MK16 cells and less efficiently in the case of TC-1. Immunizing experiments in which non-oncogenic doses of RV infected TC-1 cells were compared with irradiated cells brought surprising results. When immunized animals were challenged withTC-1 cells, the irradiated cells proved to be a better immunogen that the infected ones. But, when challenged with MK16 cells the opposite was true. This difference was associated with the different properties of the cell lines tested.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA301%2F05%2F2240" target="_blank" >GA301/05/2240: Immunological mechanisms in anticancer effect of oncolytic virus</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
57
Issue of the periodical within the volume
3
Country of publishing house
SK - SLOVAKIA
Number of pages
8
Pages from-to
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UT code for WoS article
000277412800003
EID of the result in the Scopus database
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