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In vitro and in vivo effects of reovirus on HPV16-transformed mice cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6230" target="_blank" >RIV/00064203:_____/10:6230 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/10:6230 RIV/00023736:_____/10:00008655

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    In vitro and in vivo effects of reovirus on HPV16-transformed mice cells

  • Original language description

    Oncolytic viruses are examined as anticancer therapeutics. In presented experiments we have employed two HPV16-transformed mouse cell lines, TC-1 and MK16, and reovirus type 3, strain Dearing (RV). Both lines are susceptible to RV and produce infectiousvirus in vitro while normal human cells are not susceptible to RV. TC-1 cells produced lesser amounts of virus, but died more rapidly than MK16. When inoculating high doses of infected cells into syngeneic animals their oncogenic activity was suppressedin the case of MK16 cells and less efficiently in the case of TC-1. Immunizing experiments in which non-oncogenic doses of RV infected TC-1 cells were compared with irradiated cells brought surprising results. When immunized animals were challenged withTC-1 cells, the irradiated cells proved to be a better immunogen that the infected ones. But, when challenged with MK16 cells the opposite was true. This difference was associated with the different properties of the cell lines tested.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/GA301%2F05%2F2240" target="_blank" >GA301/05/2240: Immunological mechanisms in anticancer effect of oncolytic virus</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Neoplasma

  • ISSN

    0028-2685

  • e-ISSN

  • Volume of the periodical

    57

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    SK - SLOVAKIA

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    000277412800003

  • EID of the result in the Scopus database