Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6354" target="_blank" >RIV/00064203:_____/10:6354 - isvavai.cz</a>

Alternative codes found

RIV/86652036:_____/10:00355461 RIV/00216208:11130/10:6354 RIV/00159816:_____/10:#0000486 RIV/00216224:14110/10:00058956

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Characterization of Lymphocyte Subsets in Patients with Common Variable Immunodeficiency Reveals Subsets of Naive Human B Cells Marked by CD24 Expression

Original language description

In patients with CVID (which is a defect of immunity-specifically failure of antibody),we usually find less mature memory B cells and multiple naive B cells and B cell specific CD27 (neg) CD21 (neg) CD38 (neg),which are rare in healthy people. In accordance with earlier studies,we have identified two groups of patients: increased frequency of normal naive cells and increased numbers of CD27 (neg) CD21 (neg) CD38 (neg) B cells. Our question was whether we can find developmental relationships between these cell types,that would help us to shed light on normal B cell development and its disorders in CVID.We were able to distinguish the two other subpopulations of naive B cells by functional tests (in vitro differentiation) and the expression of IgM and CD24, which correspond to follicular (FO) I and FO II cells described in mice.We assume that the CD27 (neg) CD21 (neg) CD38 (neg) B cells,which are found in increased numbers in some patients with CVID,develop from FO I cell through loss of

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EC - Immunology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Immunology

ISSN

0022-1767

e-ISSN

—

Volume of the periodical

185

Issue of the periodical within the volume

11

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

—

UT code for WoS article

000284311500007

EID of the result in the Scopus database

—