Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7027" target="_blank" >RIV/00064203:_____/11:7027 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/11:7027

Result on the web

<a href="http://www.ncbi.nlm.nih.gov/pubmed/21057553" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21057553</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT

Original language description

Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and require timely antiviral treatment. We have investigated the functional signatures of CMV-specific CD4+ and CD8+ T-cells in 191 samples from 118 individuals. We compared healthy donors with both patients with high and undetectable viral loads, and those who controlled and did not control their CMV reactivations. Polychromatic flow-cytometric measurements of CD154 (CD40L), intracellular cytokines (IFN gamma, IL2) and a degranulation marker (CD107a) allowed us to assess the functional status of various T-cells simultaneously. We found that dual IFN gamma/IL2-producing CD8+ T-cells were present in patients controlling their CMV reactivations but absent from non-controllers. CD8+ T-cells that produce only IFN gamma were the most abundant subtype, but they most likely represent non-protect

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NS9996" target="_blank" >NS9996: CMV specific immune reconstitution after allogeneic hematopoietic stem cell transplantation</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bone Marrow Transplantation

ISSN

0268-3369

e-ISSN

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Volume of the periodical

46

Issue of the periodical within the volume

8

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

1089-1098

UT code for WoS article

000293779000009

EID of the result in the Scopus database

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