Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7165" target="_blank" >RIV/00064203:_____/11:7165 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7165
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21821607" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21821607</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Sublingual isosorbide dinitrate for the detection of obstruction in hypertrophic cardiomyopathy
Original language description
Aims Hypertrophic cardiomyopathy (HCM) is predominantly associated with left ventricular outflow tract (LVOT) obstruction. The assessment of the obstruction with a provoking test should be a routine part of HCM evaluation. The aim of the study was to determine the utility of a sublingual spray application of isosorbide dinitrate (ISDN) for detection of an obstruction. Methods and results We have prospectively analysed 77 consecutive HCM patients, measuring the LVOT gradient at rest, using the sublingualspray application of ISDN (2.5 mg; after 2, 5, and 10 min), and with exercise echocardiography. An obstruction was defined as a gradient >= 30 mmHg. An obstruction was present in 15 patients (19%) at rest, in 42 patients (55%) after ISDN, and in 55 patients (71%) after exercise. The ISDN test had a sensitivity of 76% and the specificity of 100% relative to exercise echocardiography, while at-rest measurements had a sensitivity of 27% and a specificity of 100%. The chronological differen
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Project
<a href="/en/project/NT11401" target="_blank" >NT11401: Implications of Sleep Apnea for the Pathophysiology of Hypertrophic Cardiomyopathy</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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