Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7271" target="_blank" >RIV/00064203:_____/11:7271 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7271 RIV/00216208:11120/11:00003577
Result on the web
<a href="http://www.ncbi.nlm.nih.gov/pubmed/21822931" target="_blank" >http://www.ncbi.nlm.nih.gov/pubmed/21822931</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Homozygous carriers of the G allele of rs4664447 of the glucagon gene (GCG) are characterised by decreased fasting and stimulated levels of insulin, glucagon and glucagon-like peptide (GLP)-1
Original language description
The glucagon gene (GCG) encodes several hormones important for energy metabolism: glucagon, oxyntomodulin and glucagon-like peptide (GLP)-1 and -2. Variants in GCG may associate with type 2 diabetes, obesity and/or related metabolic traits. GCG was re-sequenced as a candidate gene in 865 European individuals. Twenty-nine variants were identified. Four variants that were considered to have a likelihood for altered functionality: rs4664447, rs7581952, Ile158Val and Trp169Ter, were genotyped in 17,584 Danes. When examined in 5,760 treatment-naive individuals, homozygous carriers of the low frequency (minor allele frequency 2.3%) G allele of rs4664447, predicted to disrupt an essential splice enhancer binding site, had lower levels of fasting plasma glucose (mean +/- SD, 4.8 +/- 1.2 vs 5.5 +/- 0.8 mmol/l, p = 0.004); fasting serum insulin (22 +/- 14 vs 42 +/- 27 pmol/l, p = 0.04); glucose-stimulated serum insulin (159 +/- 83 vs 290 +/- 183 pmol/l, p = 0.01) and adult height (165 +/- 10 vs
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Diabetologia
ISSN
0012-186X
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
11
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
2820-2831
UT code for WoS article
000295679800011
EID of the result in the Scopus database
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