Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F11%3A7571" target="_blank" >RIV/00064203:_____/11:7571 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7571
Result on the web
<a href="http://actavet.vfu.cz/pdf/201180040385.pdf" target="_blank" >http://actavet.vfu.cz/pdf/201180040385.pdf</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Evaluation of toxicity after periocular and intravitreal administration of carboplatin in rabbit eyes
Original language description
The aim of this study was to characterize the extent of toxicity of focal carboplatin administration and to identify the dose limiting toxicity in rabbit eyes depending on administered concentrations.The dose limiting toxicity was reached in group II after periocular injection of 30 mg of carboplatin and in group III after intravitreal injection of 0.05 mg of carboplatin. No systemic toxicity was observed in any group.Focal carboplatin administration may decrease systemic exposure to this cytotoxic drugin the retinoblastoma treatment. This moreover suggests that focal carboplatin administration is a promising approach and challenge for advanced retinoblastoma chemotherapy.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Project
<a href="/en/project/NR9532" target="_blank" >NR9532: Measurement of the concentration of cytostatics in the vitreous cavity of rabbits eye ball after trancorneal and subconjunctival administration</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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