Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293070" target="_blank" >RIV/00064203:_____/14:10293070 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/14:10293070
Result on the web
<a href="http://dx.doi.org/10.5507/bp.2012.106" target="_blank" >http://dx.doi.org/10.5507/bp.2012.106</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2012.106" target="_blank" >10.5507/bp.2012.106</a>
Alternative languages
Result language
angličtina
Original language name
Retinal toxicity after repeated intravitreal carboplatin injection into rabbit eyes
Original language description
Background. The aim of this study was to assess retinal toxicity in a rabbit model after carboplatin delivered as repeated transcorneal intravitreal injection, in order to determine the highest possible safe dose for use in human retinoblastoma "seeding"tumor chemotherapy. Methods and Results. We used six albino rabbits in an in vivo experiment and injected 0.008 mg of carboplatin intra-vitreally (iv) 4 times at two-week intervals. 0.08 mL saline was injected into the left eye. We recorded electroretinograms (ERGs) before the first carboplatin injection and after the fourth injection. Platinum concentration was measured 1 h after the fifth additional injection. We found reduced dark-adapted b-wave amplitudes and, light-adapted b-wave and a-wave amplitudes. The differences between right and left eyes was significant but we found no histopathologic retinal changes. Conclusions. 0.008 mg of carboplatin is probably the highest possible safe dose for the treatment of retinoblastoma patient
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical Papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
158
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
5
Pages from-to
552-556
UT code for WoS article
000347173200009
EID of the result in the Scopus database
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