Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: Alternative retinoblastoma treatment

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8270" target="_blank" >RIV/00064203:_____/12:8270 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/12:8270

Result on the web

<a href="http://dx.doi.org/10.5507/bp.2011.068" target="_blank" >http://dx.doi.org/10.5507/bp.2011.068</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Topotecan vitreous and plasma levels and retinal toxicity after transcorneal intravitreal delivery in healthy albino rabbits: Alternative retinoblastoma treatment

Original language description

Aim. To determine intravitreal and plasma concentrations and retinal toxicity after transcorneal intravitreal injection of 1 mu g and 2 mu g of topotecan (Hycamtin). Method. Twelve healthy albino rabbits were included in this in vivo experiment. Six anesthetized albino rabbits received a single transcorneal intravitreal injection of 1 mu g (group A) or 2 mu g (group B) of topotecan. Vitreous and blood samples were collected until 168 h. Left eyes were treated with the same volume of saline. Plasma and vitreous levels of topotecan were determined by high-performance liquid chromatography. Area under the plasma concentration time curve (AUC) was calculated using trapezoidal rule. Clinical evidence of toxicity was classified into four grades according toanatomical structures. Electroretinograms (ERGs) were recorded. Results. Time to maximum concentration was observed up to 2 h after drug injection in group A whereas up to 1 h in group B. Low levels of topotecan were detected in plasma in

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomedical Papers

ISSN

1213-8118

e-ISSN

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Volume of the periodical

156

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

318-323

UT code for WoS article

000312983100006

EID of the result in the Scopus database

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