Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6375" target="_blank" >RIV/00064203:_____/10:6375 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/10:6375

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Intravitreal carboplatin concentration and area under concentration versus time curve after intravitreal and periocular delivery

Original language description

PURPOSE. To determine platinum (Pt) concentrations and area under the concentration versus time curve (AUC) of the vitreous humor after periocular or transcorneal intravitreal administration of carboplatin in rabbits. METHODS. Eighteen albino rabbits were included in an in vivo experiment. Each animal received a single dose of either 30 mg of carboplatin by periocular injection (POI30 group: n=6) or 15 mg by periocular injection (POI15 group: n=6), or 0.05 mg by transcorneal intravitreal injection (TIIgroup: n=6), respectively, into the right eye. RESULTS. Pt concentration was mostly <1 mg/L (0-3.15 mg/L) in the vitreous humor samples and >= 2 mg/L (2.33-7.3 mg/L) in the blood samples 1 hour after administration in POI groups. Markedly higher Pt concentrations were found 1 hour after intravitreal (Ill) administration (10.285-66.759 mg/L) and decreased below 1 mg/L no less than 168 hours after administration.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry

OECD FORD branch

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Project

<a href="/en/project/NR9532" target="_blank" >NR9532: Measurement of the concentration of cytostatics in the vitreous cavity of rabbits eye ball after trancorneal and subconjunctival administration</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European Journal of Ophthalmology

ISSN

1120-6721

e-ISSN

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Volume of the periodical

20

Issue of the periodical within the volume

4

Country of publishing house

IT - ITALY

Number of pages

7

Pages from-to

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UT code for WoS article

000280191600016

EID of the result in the Scopus database

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