Spatial navigation impairment is proportional to right hippocampal volume
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F12%3A8061" target="_blank" >RIV/00064203:_____/12:8061 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/12:00390000 RIV/00216208:11130/12:8061 RIV/61383082:_____/12:#0000131 RIV/00159816:_____/12:#0000958 RIV/00216208:11110/12:11841
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1121588109" target="_blank" >http://dx.doi.org/10.1073/pnas.1121588109</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Spatial navigation impairment is proportional to right hippocampal volume
Original language description
Cognitive deficits in older adults attributable to Alzheimer's disease (AD) pathology are featured early on by hippocampal impairment. Among these individuals, deterioration in spatial navigation, manifested by poor hippocampus-dependent allocentric navigation, may occur well before the clinical onset of dementia. Our aim was to determine whether allocentric spatial navigation impairment would be proportional to right hippocampal volume loss irrespective of general brain atrophy. We also contrasted therespective spatial navigation scores of the real-space human Morris water maze with its corresponding 2D computer version. We included 42 cognitively impaired patients with either amnestic mild cognitive impairment (n = 23) or mild and moderate AD (n = 19), and 14 cognitively intact older controls. All participants underwent 1.5T MRI brain scanning with subsequent automatic measurement of the total brain and hippocampal (right and left) volumes. Allocentric spatial navigation was tested
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
109
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
2590-2594
UT code for WoS article
000300489200084
EID of the result in the Scopus database
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