Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10210541" target="_blank" >RIV/00064203:_____/14:10210541 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10210541

Result on the web

<a href="http://dx.doi.org/10.1038/modpathol.2013.193" target="_blank" >http://dx.doi.org/10.1038/modpathol.2013.193</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/modpathol.2013.193" target="_blank" >10.1038/modpathol.2013.193</a>

Result language

angličtina

Original language name

Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology

Original language description

Patients with complete androgen insensitivity syndrome are at an increased risk for the development of gonadal germ cell cancer. Residual androgen receptor (AR) activity and abnormal gonadal location may influence the survival of atypical germ cells andthe development of other histopathological features. To assess this, we evaluated 37 gonads from 19 patients with complete androgen insensitivity (ranging in age from 3 months to 18 years). Histological abnormalities were examined using hematoxylin and eosin-stained sections and sections stained for POU5F1 and KITLG, markers of early changes in germ cells at risk for malignant transformation. Hamartomatous nodules (HNs), Leydig cell hyperplasia (LCH), decreased germ cells, tubular atrophy and stromal fibrosis were more pronounced as age increased (P<0.001). Expected residual AR activity acted as a positive predictor only for non-malignant germ cell survival in (post)pubertal patients (P<0.05). Immunohistochemical studies indicated that

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Modern Pathology

ISSN

0893-3952

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

5

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

721-730

UT code for WoS article

000335428600010

EID of the result in the Scopus database

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