Structural changes in the bronchial mucosa of young children at risk of developing asthma

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F14%3A10293025" target="_blank" >RIV/00064203:_____/14:10293025 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/14:10293025

Result on the web

<a href="http://dx.doi.org/10.1111/pai.12119" target="_blank" >http://dx.doi.org/10.1111/pai.12119</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/pai.12119" target="_blank" >10.1111/pai.12119</a>

Result language

angličtina

Original language name

Structural changes in the bronchial mucosa of young children at risk of developing asthma

Original language description

Background Allergen-specific immunotherapy (IT) is widely used to treat allergic diseases. The molecular mechanisms have not been clarified yet completely. The present work was undertaken to analyze the effect of IT in the activation of NF-kappa B. Methods Neutrophils from 15 pollen-allergic IT-treated patients, 10 untreated pollen-allergic patients, and 10 healthy donors were in vitro stimulated with LPS. NF-kappa B activation (p65/p52) was measured in their nuclear extracts by enzyme-linked immunosorbent assay (ELISA). I kappa B alpha phosphorylation, NF-kappa B-repressing factor (NRF) activation, and thromboxane A(2) (TXA(2)) and Interleukin-8 (IL-8) release were measured by ELISA. Results There was a positive correlation between the score of symptoms and NF-kappa B activation in human neutrophils. IT significantly decreased NF-kappa B activation levels in neutrophils compared with neutrophils from untreated patients. I kappa B alpha phosphorylation and NRF activation levels were, r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FG - Paediatrics

OECD FORD branch

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Project

<a href="/en/project/NT11444" target="_blank" >NT11444: Early symptoms of bronchial asthma in children - functional and morphological consequences of the disease</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pediatric Allergy and Immunology

ISSN

0905-6157

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

2

Country of publishing house

DK - DENMARK

Number of pages

7

Pages from-to

136-142

UT code for WoS article

000332968000005

EID of the result in the Scopus database

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