Increased proportions of gamma delta T lymphocytes in atypical SCID associate with disease manifestations

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F19%3A10394340" target="_blank" >RIV/00064203:_____/19:10394340 - isvavai.cz</a>

Alternative codes found

RIV/00216208:11130/19:10394340

Result on the web

<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7DQA6WXkb7" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=7DQA6WXkb7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clim.2018.11.006" target="_blank" >10.1016/j.clim.2018.11.006</a>

Result language

angličtina

Original language name

Increased proportions of gamma delta T lymphocytes in atypical SCID associate with disease manifestations

Original language description

Severe combined immunodeficiencies (SCID) comprise a group of genetic diseases characterized by abrogated development of T lymphocytes. In some case reports of atypical SCID patients elevated proportions of gamma delta T lymphocytes have been reported. However, it is unknown whether these gamma delta T cells modulate or reflect the patient&apos;s clinical phenotype. We investigated the frequency of elevated gamma delta T cell proportions and associations with clinical disease manifestations in a cohort of 76 atypical SCID patients. Increased proportions of gamma delta T lymphocytes were present in approximately 600/0 of these patients. Furthermore, we identified positive correlations between elevated proportions of gamma delta T cells and the occurrence of CMV infections and autoimmune cytopenias. We discuss that CMV infections might trigger an expansion of gamma delta T lymphocytes, which could drive the development of autoimmune cytopenias. We advocate that atypical SCID patients should be screened for elevated proportions of gamma delta T lymphocytes, CMV infection and autoimmune cytopenias.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Immunology

ISSN

1521-6616

e-ISSN

—

Volume of the periodical

201

Issue of the periodical within the volume

April

Country of publishing house

US - UNITED STATES

Number of pages

5

Pages from-to

30-34

UT code for WoS article

000463692100005

EID of the result in the Scopus database

2-s2.0-85062236926