Patent foramen ovale and the risk of cerebral infarcts in acute pulmonary embolism - a prospective observational study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F18%3AN0000095" target="_blank" >RIV/00098892:_____/18:N0000095 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00104069 RIV/61989592:15110/18:73590770

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Patent foramen ovale and the risk of cerebral infarcts in acute pulmonary embolism - a prospective observational study

Original language description

BACKGROUND: Pulmonary embolism (PE) is associated with a risk of consecutive paradoxical embolism with brain infarction through a patent foramen ovale (PFO). The aims of this study were to assess the rate of new ischemic brain lesions (IBLs) using magnetic resonance imaging (MRI) during a 12-month follow-up period with anticoagulation and to evaluate the potential relationship with the presence of PFO on transesophageal echocardiography (TEE). SUBJECTS AND METHODS: Seventy-eight patients with acute PE underwent baseline contrast TEE with brain MRI. After the 12-month follow-up, 58 underwent brain MRI. The rates of MRI documenting new IBLs were measured based on the presence of PFO. RESULTS: PFO was detected in 31 patients (39.7 %). At baseline MRI, IBL was present in 39 of 78 patients (50 - %). The presence of IBL was not significantly higher in patients with PFO than in patients without PFO (20 - 64.5 % patients with PFO) versus 19 - 40.4 % without PFO of 39 patients with baseline IBL, P = .063). At the follow-up MRI, in the group with new IBL (9 of 58 patients, 15.5 %), the number of patients with PFO was significantly higher than that without PFO (7 - 33.3 % versus 2 - 5.4 %, P = .008). PFO was identified as an independent predictor of new IBL (odds ratio 4.6 : 1.6-47.4, P = .008). CONCLUSIONS: The presence of PFO was associated with new IBL in patients with PE. These patients are at a higher risk of ischemic stroke despite effective anticoagulation therapy.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30201 - Cardiac and Cardiovascular systems

Project

<a href="/en/project/NV17-30101A" target="_blank" >NV17-30101A: Risk factors of ischemic stroke in young patients and relation with epidemiologic, social and economic parameters and life style</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Stroke & Cerebrovascular Diseases

ISSN

1052-3057

e-ISSN

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Volume of the periodical

27

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

8

Pages from-to

257-264

UT code for WoS article

000419585800019

EID of the result in the Scopus database

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