Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism—A Prospective Observational Study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73590770" target="_blank" >RIV/61989592:15110/18:73590770 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/18:00104069 RIV/00098892:_____/18:N0000095
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1052305717304755?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1052305717304755?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2017.09.004" target="_blank" >10.1016/j.jstrokecerebrovasdis.2017.09.004</a>
Alternative languages
Result language
angličtina
Original language name
Patent Foramen Ovale and the Risk of Cerebral Infarcts in Acute Pulmonary Embolism—A Prospective Observational Study
Original language description
BACKGROUND: Pulmonary embolism (PE) is associated with a risk of consecutive paradoxical embolism with brain infarction through a patent foramen ovale (PFO). The aims of this study were to assess the rate of new ischemic brain lesions (IBLs) using magnetic resonance imaging (MRI) during a 12-month follow-up period with anticoagulation and to evaluate the potential relationship with the presence of PFO on transesophageal echocardiography (TEE). SUBJECTS AND METHODS: Seventy-eight patients with acute PE underwent baseline contrast TEE with brain MRI. After the 12-month follow-up, 58 underwent brain MRI. The rates of MRI documenting new IBLs were measured based on the presence of PFO. RESULTS: PFO was detected in 31 patients (39.7%). At baseline MRI, IBL was present in 39 of 78 patients (50%). The presence of IBL was not significantly higher in patients with PFO than in patients without PFO (20 [64.5% patients with PFO] versus 19 [40.4% without PFO] of 39 patients with baseline IBL, P = .063). At the follow-up MRI, in the group with new IBL (9 of 58 patients, 15.5%), the number of patients with PFO was significantly higher than that without PFO (7 [33.3%] versus 2 [5.4%], P = .008). PFO was identified as an independent predictor of new IBL (odds ratio 4.6 [1.6-47.4], P = .008). CONCLUSIONS: The presence of PFO was associated with new IBL in patients with PE. These patients are at a higher risk of ischemic stroke despite effective anticoagulation therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30201 - Cardiac and Cardiovascular systems
Result continuities
Project
<a href="/en/project/NV17-30101A" target="_blank" >NV17-30101A: Risk factors of ischemic stroke in young patients and relation with epidemiologic, social and economic parameters and life style</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Stroke & Cerebrovascular Diseases
ISSN
1052-3057
e-ISSN
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Volume of the periodical
27
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
357-364
UT code for WoS article
000419585800019
EID of the result in the Scopus database
2-s2.0-85030864185