Case Report: Concomitant Alzheimer’s and Lewy-Related Pathology Extending the Spectrum of Underlying Pathologies of Corticobasal Syndrome

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F21%3AN0000082" target="_blank" >RIV/00098892:_____/21:N0000082 - isvavai.cz</a>

Result on the web

<a href="https://www.frontiersin.org/articles/10.3389/fnins.2021.742042/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fnins.2021.742042/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fnins.2021.742042" target="_blank" >10.3389/fnins.2021.742042</a>

Result language

angličtina

Original language name

Case Report: Concomitant Alzheimer’s and Lewy-Related Pathology Extending the Spectrum of Underlying Pathologies of Corticobasal Syndrome

Original language description

Corticobasal syndrome (CBS) is clinically characterized by progressive asymmetric rigidity and apraxia together with symptoms suggestive of cortical involvement and basal ganglia dysfunction. The spectrum of neurodegenerative diseases that can manifest with CBS is wide. The associations of CBS with corticobasal degeneration, progressive supranuclear palsy, Alzheimer’s disease, frontotemporal lobar degenerations, Creutzfeldt–Jakob disease, or diffuse Lewy body pathology have been reported. We describe the case of a 71-year-old woman with CBS. The histopathological examination of brain tissue revealed concomitant pathology corresponding to the limbic stage of Lewy-related pathology and the intermediate stage of Alzheimer’s-type pathology. To date, there have been only a few cases with a similar combination of pathology manifesting with the CBS phenotype that have been described in the literature. The extent and distribution of pathological changes in these cases were somewhat different from ours, and significance for clinical manifestation was attributed to only one of these pathologies. In our case, we assume that both types of pathology contributed to the development of the disease, considering the presumed specific spread of both types of pathological processes according to Braak’s staging. Our case expands the spectrum of neurodegenerative pathological processes that may manifest with the typical CBS phenotype. Also, it points out the importance of identifying specific biomarkers that would enable more accurate in vivo differential diagnosis and more accurate determination of the underlying pathological processes of these diseases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30210 - Clinical neurology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Frontiers in Neuroscience

ISSN

1662-4548

e-ISSN

1662-453X

Volume of the periodical

15

Issue of the periodical within the volume

November

Country of publishing house

CH - SWITZERLAND

Number of pages

7

Pages from-to

742042

UT code for WoS article

000719840800001

EID of the result in the Scopus database

2-s2.0-85119421892