Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00098892%3A_____%2F22%3A10157730" target="_blank" >RIV/00098892:_____/22:10157730 - isvavai.cz</a>
Alternative codes found
RIV/61989592:15110/22:73613129
Result on the web
<a href="https://link.springer.com/article/10.1007/s11914-022-00720-3" target="_blank" >https://link.springer.com/article/10.1007/s11914-022-00720-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s11914-022-00720-3" target="_blank" >10.1007/s11914-022-00720-3</a>

Result language
angličtina
Original language name
Macrophage Polarization and the Osteoimmunology of Periprosthetic Osteolysis
Original language description
Purpose of Review: Joint replacement has revolutionized the treatment of end-stage arthritis. We highlight the key role of macrophages in the innate immune system in helping to ensure that the prosthesis-host interface remains biologically robust. Recent Findings: Osteoimmunology is of great interest to researchers investigating the fundamental biological and material aspects of joint replacement. Constant communication between cells of the monocyte/macrophage/osteoclast lineage and the mesenchymal stem cell-osteoblast lineage determines whether a durable prosthesis-implant interface is obtained, or whether implant loosening occurs. Tissue and circulating monocytes/macrophages provide local surveillance of stimuli such as the presence of byproducts of wear and can quickly polarize to pro- and anti-inflammatory phenotypes to re-establish tissue homeostasis. When these mechanisms fail, periprosthetic osteolysis results in progressive bone loss and painful failure of mechanical fixation. Summary: Immune modulation of the periprosthetic microenvironment is a potential intervention to facilitate long-term durability of prosthetic interfaces.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30211 - Orthopaedics

Project
<a href="/en/project/NU21-06-00370" target="_blank" >NU21-06-00370: Differentiation of low-grade infection in THA and TKA from aseptic complications using immunocytologic analysis and machine learning</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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