AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061138" target="_blank" >RIV/00159816:_____/14:00061138 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1089/neu.2014.3347" target="_blank" >http://dx.doi.org/10.1089/neu.2014.3347</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1089/neu.2014.3347" target="_blank" >10.1089/neu.2014.3347</a>

Result language
angličtina
Original language name
AQP4 tag single nucleotide polymorphisms in patients with traumatic brain injury
Original language description
Accumulating evidence suggests that the extent of brain injury and the clinical outcome after Traumatic Brain Injury (TBI) are modulated, to some degree, by genetic variants. Aquaporin-4 (AQP4) is the predominant water channel in the central nervous system and plays a critical role in controlling the water content of brain cells and the development of brain edema after TBI. We sought to investigate the influence of the AQP4 gene region on the patients' outcome after TBI by genotyping tag single nucleotide polymorphisms (SNPs) along AQP4 gene. A total of 363 TBI patients (19.6% female) were prospectively evaluated. Data including the Glasgow Coma Scale (GCS) scores at admission, the presence of intracranial haemorrhage and the 6-month Glasgow Outcome Scale (GOS) scores were collected. Seven tag single SNPs across AQP4 gene were identified based on the HapMap data. Using logistic regression analyses SNPs and haplotypes were tested for associations with 6-month GOS after adjusting for age
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
—

Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)