Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00064385" target="_blank" >RIV/00159816:_____/15:00064385 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1097/FPC.0000000000000161" target="_blank" >http://dx.doi.org/10.1097/FPC.0000000000000161</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/FPC.0000000000000161" target="_blank" >10.1097/FPC.0000000000000161</a>

Result language

angličtina

Original language name

Effect of angiotensin-converting enzyme tag single nucleotide polymorphisms on the outcome of patients with traumatic brain injury

Original language description

BackgroundGenetic variants appear to influence, at least to some degree, the extent of brain injury and the clinical outcome of patients who have sustained a traumatic brain injury (TBI). Angiotensin-converting enzyme (ACE) is a zinc metallopeptidase that is implicated in the regulation of blood pressure and cerebral circulation. ACE gene polymorphisms were found to regulate serum ACE enzyme activity.ObjectiveThe present study aimed to investigate possible influence of ACE gene region variants on patients' outcome after TBI.Patients and methodsIn total, 363 TBI patients prospectively enrolled in the study were genotyped for five tag single nucleotide polymorphisms (SNPs) across the ACE gene. Using logistic regression analyses, tag SNPs and their constructed haplotypes were tested for associations with 6-month Glasgow Outcome Scale scores, after adjustment for age, sex, Glasgow Coma Scale scores at admission, and the presence of a hemorrhagic event in the initial computed tomography sca

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FR - Pharmacology and apothecary chemistry

OECD FORD branch

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Project

<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Pharmacogenetics and Genomics

ISSN

1744-6872

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

6

Pages from-to

485-490

UT code for WoS article

000361476500002

EID of the result in the Scopus database

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