Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061228" target="_blank" >RIV/00159816:_____/14:00061228 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/iep.12094" target="_blank" >http://dx.doi.org/10.1111/iep.12094</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/iep.12094" target="_blank" >10.1111/iep.12094</a>
Alternative languages
Result language
angličtina
Original language name
Melatonin potentiates the anti-tumour effect of pravastatin in rat mammary gland carcinoma model
Original language description
Oncological research indicated a possible role of statins in the risk reduction of certain malignancies. The purpose of this experiment was to examine the chemopreventive effects of pravastatin alone and in combination with pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female rats. Pravastatin was administered dietary (100 mg/kg) and melatonin in a water solution (20 mýg/ml). Chemoprevention began 7 days prior to carcinogen administration and subsequently continued 15 weeks until to autopsy. At autopsy, mammary tumours were removed and prepared for histopathological and immunohistochemical analysis. Parameters of experimental carcinogenesis, mechanism of action (biomarkers of apoptosis, angiogenesis and proliferation) and side effects after long-term treatment in animals were assessed. Pravastatin alone suppressed tumour frequency by 20.5% and average tumour volume by 15% compared with controls. Combined administration of the drugs de
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
International Journal of Experimental Pathology
ISSN
0959-9673
e-ISSN
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Volume of the periodical
96
Issue of the periodical within the volume
6
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
401-410
UT code for WoS article
000346972300004
EID of the result in the Scopus database
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