Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00063189" target="_blank" >RIV/00159816:_____/14:00063189 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.acthis.2014.09.010" target="_blank" >http://dx.doi.org/10.1016/j.acthis.2014.09.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.acthis.2014.09.010" target="_blank" >10.1016/j.acthis.2014.09.010</a>

Result language
angličtina
Original language name
Combination of Pitavastatin and melatonin shows partial antineoplastic effects in a rat breast carcinoma model
Original language description
Our previous results indicated significant tumor-suppressive effects of different statins in rat mammary carcinogenesis. The purpose of this experiment was to examine the chemopreventive effects of Pitavastatin alone and in combination with the pineal hormone melatonin in the model of N-methyl-N-nitrosourea-induced mammary carcinogenesis in female Sprague-Dawley rats. Pitavastatin was administered dietary (10 mg/kg) and melatonin in an aqueous solution (20 mu g/ml). Chemoprevention began 7 days prior tocarcinogen administration and subsequently continued for 15 weeks until autopsy. At autopsy, mammary tumors were removed and prepared for histopathological and immunohistochemical analysis. Compared to controls, Pitavastatin alone reduced average tumorvolume by 58% and lengthened latency by 8 days; on the other hand, the drug increased tumor frequency by 23%. Combined administration of Pitavastatin with melatonin decreased tumor frequency by 23%, tumor volume by 44% and lengthened tumo
Czech name
—
Czech description
—

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
—

Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)