Vasospasm of the flap pedicle - The new experimental model on rat

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F14%3A00061520" target="_blank" >RIV/00159816:_____/14:00061520 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/14:00080157
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Vasospasm of the flap pedicle - The new experimental model on rat
Original language description
Background: An experimental model for testing vasodilating drugs on vasospasm caused by standardized traumatisation of a pedicle has not been described yet. The aim of this study was to develop such model and to compare the effects of different types ofsurgical manipulations that can provoke vasospasm during flap dissection. Material and methods: The pedicled groin flap was dissected in 185 male Wistar rats under standardised conditions. The blood perfusion curves of the flap were obtained using the Laser Doppler flow-meter. The vasospasm was provoked by the following manoeuvres: pulling on the pedicle; compression of the pedicle by vascular clamps; dissection of the vessels and by presence of blood around the pedicle. The perfusion recording curves were processed and two important time periods describing the progress of spasm were extracted. Combined non-parametrical ANOVA and WILCOXON tests were used to compare the time parameters between the groups. On the basis of statistical eval
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FJ - Surgery including transplantology
OECD FORD branch
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Project
<a href="/en/project/NR8368" target="_blank" >NR8368: Vasospams of Microsurgical Free Flaps and Possibilities of Treatment</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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