B-type natriuretic peptide and heart failure: what can we learn from clinical trials?
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F15%3A00063011" target="_blank" >RIV/00159816:_____/15:00063011 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1111/1440-1681.12418" target="_blank" >http://dx.doi.org/10.1111/1440-1681.12418</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/1440-1681.12418" target="_blank" >10.1111/1440-1681.12418</a>
Alternative languages
Result language
angličtina
Original language name
B-type natriuretic peptide and heart failure: what can we learn from clinical trials?
Original language description
The B-type natriuretic peptide (BNP), may favor natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient who had poor or worsening renal function. Several randomized clinical trials have tested the hypothesisthat infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these has resulted in a better outcome. The current challenge for BNP research in acute HF lies in a failure of concept and reluctance to abandon a demonstrably ineffectual research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP as well as a better integration of basicand clinical science.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/ED1.100%2F02%2F0123" target="_blank" >ED1.100/02/0123: St. Anne´s University Hospital Brno - International Clinical Research Center (FNUSA-ICRC)</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical and Experimental Pharmacology and Physiology
ISSN
1440-1681
e-ISSN
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Volume of the periodical
42
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
881-887
UT code for WoS article
000360099000001
EID of the result in the Scopus database
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