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The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F20%3A00116163" target="_blank" >RIV/00216224:14110/20:00116163 - isvavai.cz</a>

  • Result on the web

    <a href="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290" target="_blank" >https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1440-1681.13290</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/1440-1681.13290" target="_blank" >10.1111/1440-1681.13290</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    The therapeutic effect of B-type natriuretic peptides in acute decompensated heart failure

  • Original language description

    B-type natriuretic peptide (BNP) exhibits roles in natriuresis and diuresis, making it an ideal drug that may aid in diuresing a fluid-overloaded patient with poor or worsening renal function. Several randomized clinical trials have tested the hypothesis that infusions of pharmacological doses of BNP to acute heart failure (HF) patients may enhance decongestion and preserve renal function in this clinical setting. Unfortunately, none of these have demonstrated beneficial outcomes. The current challenge for BNP research in acute HF lies in addressing a failure of concept and a reluctance to abandon an ineffective research model. Future success will necessitate a detailed understanding of the mechanism of action of BNP, as well as better integration of basic and clinical science.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30104 - Pharmacology and pharmacy

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Pharmacology and Physiology

  • ISSN

    0305-1870

  • e-ISSN

    1440-1681

  • Volume of the periodical

    47

  • Issue of the periodical within the volume

    7

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    14

  • Pages from-to

    1120-1133

  • UT code for WoS article

    000520715900001

  • EID of the result in the Scopus database

    2-s2.0-85082083547