Changes in Phonation and Their Relations with Progress of Parkinson's Disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F18%3A00069501" target="_blank" >RIV/00159816:_____/18:00069501 - isvavai.cz</a>

Alternative codes found

RIV/00216305:26220/19:PU130088 RIV/65269705:_____/18:00069501 RIV/00216224:14740/18:00106964

Result on the web

<a href="https://www.mdpi.com/2076-3417/8/12/2339" target="_blank" >https://www.mdpi.com/2076-3417/8/12/2339</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app8122339" target="_blank" >10.3390/app8122339</a>

Result language

angličtina

Original language name

Changes in Phonation and Their Relations with Progress of Parkinson's Disease

Original language description

Hypokinetic dysarthria, which is associated with Parkinson&apos;s disease (PD), affects several speech dimensions, including phonation. Although the scientific community has dealt with a quantitative analysis of phonation in PD patients, a complex research revealing probable relations between phonatory features and progress of PD is missing. Therefore, the aim of this study is to explore these relations and model them mathematically to be able to estimate progress of PD during a two-year follow-up. We enrolled 51 PD patients who were assessed by three commonly used clinical scales. In addition, we quantified eight possible phonatory disorders in five vowels. To identify the relationship between baseline phonatory features and changes in clinical scores, we performed a partial correlation analysis. Finally, we trained XGBoost models to predict the changes in clinical scores during a two-year follow-up. For two years, the patients&apos; voices became more aperiodic with increased microperturbations of frequency and amplitude. Next, the XGBoost models were able to predict changes in clinical scores with an error in range 11-26%. Although we identified some significant correlations between changes in phonatory features and clinical scores, they are less interpretable. This study suggests that it is possible to predict the progress of PD based on the acoustic analysis of phonation. Moreover, it recommends utilizing the sustained vowel /i/ instead of /a/.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Applied Sciences-Basel

ISSN

2076-3417

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

12

Country of publishing house

CH - SWITZERLAND

Number of pages

18

Pages from-to

2339

UT code for WoS article

000455145000007

EID of the result in the Scopus database

2-s2.0-85057112571