Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070694" target="_blank" >RIV/00159816:_____/19:00070694 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/19:00108608

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1388245718313762?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinph.2018.11.013" target="_blank" >10.1016/j.clinph.2018.11.013</a>

Result language

angličtina

Original language name

Impairment of brain functions in Parkinson's disease reflected by alterations in neural connectivity in EEG studies: A viewpoint

Original language description

Clinical symptoms of Parkinson&apos;s disease (PD) are accompanied by pathological phenomena detected locally in the basal ganglia (BG) as changes in local field potentials (LFPs) and also in cortical regions by electroencephalography (EEG). The literature published mainly between 2000 and 2017 was reviewed with an emphasis on approaches emerging after 2000, in particular on oscillatory dynamics, connectivity studies, and deep brain stimulation. Eighty-five articles were reviewed. The main observations were a general slowing of background activity, excessive synchronization of beta activity, and disturbed movement-related gamma oscillations in the BG and in the cortico-subcortical and cortico-cortical motor loops, suppressible by dopaminergic medication as well as by high-frequency deep brain stimulation (DBS). Non-motor symptoms are related mainly to changes in the alpha frequency range. EEG parameters can be useful in defining the risk of dementia in PD. Further progress was reported recently using advanced analytical technologies and high-performance computing (graph theory). Detailed knowledge of LFPs in PD enabled progress particularly in DBS therapy, which requires optimizing the clinical effect and minimizing adverse side effects. The neurocognitive networks and their dysfunction in PD and DBS therapy are promising targets for future research. (C) 2018 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/NV16-33798A" target="_blank" >NV16-33798A: Modulation of functional connectivity of the large scale cortical networks by STN DBS</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Neurophysiology

ISSN

1388-2457

e-ISSN

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Volume of the periodical

130

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

239-247

UT code for WoS article

000456164600006

EID of the result in the Scopus database

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