Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985807%3A_____%2F24%3A00602309" target="_blank" >RIV/67985807:_____/24:00602309 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/24:00138461 RIV/00159816:_____/24:00081262 RIV/00023752:_____/24:43921414
Result on the web
<a href="https://doi.org/10.1038/s41598-024-80630-9" target="_blank" >https://doi.org/10.1038/s41598-024-80630-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41598-024-80630-9" target="_blank" >10.1038/s41598-024-80630-9</a>
Alternative languages
Result language
angličtina
Original language name
Revealing Connectivity Patterns of Deep Brain Stimulation Efficacy in Parkinson’s Disease
Original language description
The aim of this work was to study the effect of deep brain stimulation of the subthalamic nucleus (STN-DBS) on the subnetwork of subcortical and cortical motor regions using the functional connectivity analysis in Parkinson’s disease (PD). The high-density source space EEG was acquired and analyzed in 43 PD subjects in DBS on and DBS off stimulation states (off medication) during a cognitive-motor task. Increased connectivity within subcortical regions and between subcortical and cortical motor regions in the high gamma band (50-100Hz) was significantly associated with the Movement Disorders Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) III improvement. Further, the whole brain connectivity patterns were evaluated to complement this finding. The connectivity patterns in low gamma (30-50Hz) and high gamma band (50-100Hz) significantly correlated with the movement improvement. Neural correlates of cognitive performance were detected in the beta (12-30Hz) and high gamma (50-100Hz) bands. Finally, a whole brain multifrequency connectivity profile was found to classify optimal and suboptimal responders to DBS with a positive predictive value of 0.77, negative predictive value of 0.55, specificity of 0.73, and sensitivity of 0.60. Specific connectivity patterns related to motor symptoms improvement after DBS and therapy responsiveness predictive connectivity profiles were uncovered.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
2045-2322
Volume of the periodical
14
Issue of the periodical within the volume
30 December
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
31652
UT code for WoS article
001389341300023
EID of the result in the Scopus database
2-s2.0-85213719845