All

What are you looking for?

All
Projects
Results
Organizations

Quick search

  • Projects supported by TA ČR
  • Excellent projects
  • Projects with the highest public support
  • Current projects

Smart search

  • That is how I find a specific +word
  • That is how I leave the -word out of the results
  • “That is how I can find the whole phrase”

Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00070971" target="_blank" >RIV/00159816:_____/19:00070971 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216305:26220/19:PU129486 RIV/00216224:14740/19:00108467

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1353802018304395?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1353802018304395?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.parkreldis.2018.10.011" target="_blank" >10.1016/j.parkreldis.2018.10.011</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Non-invasive stimulation of the auditory feedback area for improved articulation in Parkinson's disease

  • Original language description

    Introduction Hypokinetic dysarthria (HD) is a common symptom of Parkinson&apos;s disease (PD) which does not respond well to PD treatments. We investigated acute effects of repetitive transcranial magnetic stimulation (rTMS) of the motor and auditory feedback area on HD in PD using acoustic analysis of speech. Methods: We used 10 Hz and 1 Hz stimulation protocols and applied rTMS over the left orofacial primary motor area, the right superior temporal gyrus (STG), and over the vertex (a control stimulation site) in 16 PD patients with HD. A cross-over design was used. Stimulation sites and protocols were randomised across subjects and sessions. Acoustic analysis of a sentence reading task performed inside the MR scanner was used to evaluate rTMS-induced effects on motor speech. Acute fMRI changes due to rTMS were also analysed. Results: The 1 Hz STG stimulation produced significant increases of the relative standard deviation of the 2nd formant (p = 0.019), i.e. an acoustic parameter describing the tongue and jaw movements. The effects were superior to the control site stimulation and were accompanied by increased resting state functional connectivity between the stimulated region and the right parahippocampal gyrus. The rTMS-induced acoustic changes were correlated with the reading task-related BOLD signal increases of the stimulated area (R = 0.654, p = 0.029). Conclusion: Our results demonstrate for the first time that low-frequency stimulation of the temporal auditory feedback area may improve articulation in PD and enhance functional connectivity between the STG and the cortical region involved in an overt speech control.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30103 - Neurosciences (including psychophysiology)

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Parkinsonism &amp; Related Disorders

  • ISSN

    1353-8020

  • e-ISSN

  • Volume of the periodical

    61

  • Issue of the periodical within the volume

    APR 2019

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    6

  • Pages from-to

    187-192

  • UT code for WoS article

    000468719900032

  • EID of the result in the Scopus database