Effects of non-invasive brain stimulation on motor speech disorder in Parkinson’s disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F18%3APU128308" target="_blank" >RIV/00216305:26220/18:PU128308 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.clinph.2018.01.030" target="_blank" >https://doi.org/10.1016/j.clinph.2018.01.030</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Effects of non-invasive brain stimulation on motor speech disorder in Parkinson’s disease
Original language description
Introduction Hypokinetic dysarthria (HD) is a common symptom of Parkinson's disease (PD) which does not respond well to PD treatments. We investigated short-term effects of repetitive transcranial magnetic stimulation (rTMS) on HD in PD using acoustic analysis of speech. Methods We used both high and low frequency rTMS applied over the right posterior superior temporal gyrus (STG), the left orofacial primary motor area, and over the vertex (a control stimulation site) in 15 PD patients using a cross-over design. Resting state seed-based functional connectivity (rs-FC) with the seed located in the stimulation site was used to unravel the neural underpinnings of rTMS-induced behavioural changes. Results Both 1 Hz and 10 Hz rTMS of the right STG induced some positive changes on HD. The major impact was observed for 1 Hz rTMS over the STG. The stimulation improved speech articulation and rhythmicity via modulation of the STG rs-FC with the parahippocampal gyrus and cerebellum. The 10 Hz rTMS of the STG
Czech name
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Czech description
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Project
<a href="/en/project/NV16-30805A" target="_blank" >NV16-30805A: Effects of non-invasive brain stimulation on hypokinetic dysarthria, micrographia, and brain plasticity in patients with Parkinson's disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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