Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F16%3A00088836" target="_blank" >RIV/00216224:14740/16:00088836 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26220/16:PU115456
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S1353802015003818" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1353802015003818</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.parkreldis.2015.09.006" target="_blank" >10.1016/j.parkreldis.2015.09.006</a>
Alternative languages
Result language
angličtina
Original language name
Impact of Parkinson's disease and levodopa on resting state functional connectivity related to speech prosody control
Original language description
Background: Impaired speech prosody is common in Parkinson's disease (PD). We assessed the impact of PD and levodopa on MRI resting-state functional connectivity (rs-FC) underlying speech prosody control. Methods: We studied 19 PD patients in the OFF and ON dopaminergic conditions and 15 age-matched healthy controls using functional MRI and seed partial least squares correlation (PLSC) analysis. In the PD group, we also correlated levodopa-induced rs-FC changes with the results of acoustic analysis. Results: The PLCS analysis revealed a significant impact of PD but not of medication on the rs-FC strength of spatial correlation maps seeded by the anterior cingulate (p = 0.006), the right orofacial primary sensorimotor cortex (OF_SM1; p = 0.025) and the right caudate head (CN; p = 0.047). In the PD group, levodopa-induced changes in the CN and OF_SM1 connectivity strengths were related to changes in speech prosody.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FH - Neurology, neuro-surgery, nuero-sciences
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PARKINSONISM & RELATED DISORDERS
ISSN
1353-8020
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
Supplement 1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
"S52"-"S55"
UT code for WoS article
000366781900012
EID of the result in the Scopus database
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