Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F23%3APU149481" target="_blank" >RIV/00216305:26220/23:PU149481 - isvavai.cz</a>

Result on the web

<a href="https://doi.org/10.1007/s00702-023-02715-5" target="_blank" >https://doi.org/10.1007/s00702-023-02715-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00702-023-02715-5" target="_blank" >10.1007/s00702-023-02715-5</a>

Result language

angličtina

Original language name

Levodopa may modulate specific speech impairment in Parkinson's disease: an fMRI study

Original language description

Hypokinetic dysarthria (HD) is a difficult-to-treat symptom affecting quality of life in patients with Parkinson’s disease (PD). Levodopa may partially alleviate some symptoms of HD in PD, but the neural correlates of these effects are not fully understood. The aim of our study was to identify neural mechanisms by which levodopa affects articulation and prosody in patients with PD. Altogether 20 PD patients participated in a task fMRI study (overt sentence reading). Using a single dose of levodopa after an overnight withdrawal of dopaminergic medication, levodopa-induced BOLD signal changes within the articulatory pathway (in regions of interest; ROIs) were studied. We also correlated levodopa-induced BOLD signal changes with the changes in acoustic parameters of speech. We observed no significant changes in acoustic parameters due to acute levodopa administration. After levodopa administration as compared to the OFF dopaminergic condition, patients showed task-induced BOLD signal decreases in the left ventral thalamus (p = 0.0033). The changes in thalamic activation were associated with changes in pitch variation (R = 0.67, p = 0.006), while the changes in caudate nucleus activation were related to changes in the second formant variability which evaluates precise articulation (R = 0.70, p = 0.003). The results are in line with the notion that levodopa does not have a major impact on HD in PD, but it may induce neural changes within the basal ganglia circuitries that are related to changes in speech prosody and articulation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/LX22NPO5107" target="_blank" >LX22NPO5107: National institute for Neurological Research</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

JOURNAL OF NEURAL TRANSMISSION

ISSN

0300-9564

e-ISSN

1435-1463

Volume of the periodical

1

Issue of the periodical within the volume

11

Country of publishing house

AT - AUSTRIA

Number of pages

7

Pages from-to

1-7

UT code for WoS article

001099133000001

EID of the result in the Scopus database

2-s2.0-85175973542