Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F19%3A00071235" target="_blank" >RIV/00159816:_____/19:00071235 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/19:00110433

Result on the web

<a href="https://link.springer.com/article/10.1007%2Fs10875-018-0577-9" target="_blank" >https://link.springer.com/article/10.1007%2Fs10875-018-0577-9</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10875-018-0577-9" target="_blank" >10.1007/s10875-018-0577-9</a>

Result language

angličtina

Original language name

Imaging of Bronchial Pathology in Antibody Deficiency: Data from the European Chest CT Group

Original language description

Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. We aimed to establish an international platform for the evaluation of bronchial pathology as assessed by chest CT and to describe the range of bronchial pathologies in patients with antibody deficiency. Ffteen immunodeficiency centres from 9 countries evaluated chest CT scans of patients with ADS using a predefined list of potential findings including an extent score for bronchiectasis. Data of 282 patients with ADS were collected. Patients with common variable immunodeficiency disorders (CVID) comprised the largest subgroup (232 patients, 82.3%). Eighty percent of CVID patients had radiological evidence of bronchial pathology including bronchiectasis in 61%, bronchial wall thickening in 44% and mucus plugging in 29%. Bronchiectasis was detected in 44% of CVID patients aged less than 20years. Cough was a better predictor for bronchiectasis than spirometry values. Delay of diagnosis as well as duration of disease correlated positively with presence of bronchiectasis. The use of consensus diagnostic criteria and a pre-defined list of bronchial pathologies allows for comparison of chest CT data in multicentre studies. Our data suggest a high prevalence of bronchial pathology in CVID due to late diagnosis or duration of disease.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30102 - Immunology

Project

<a href="/en/project/EF15_003%2F0000469" target="_blank" >EF15_003/0000469: Cetocoen Plus</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Clinical Immunology

ISSN

0271-9142

e-ISSN

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Volume of the periodical

39

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

45-54

UT code for WoS article

000458867500011

EID of the result in the Scopus database

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