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EN
ČeštinaEnglish

Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00082894" target="_blank" >RIV/00216224:14110/15:00082894 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1111/cei.12459" target="_blank" >http://dx.doi.org/10.1111/cei.12459</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1111/cei.12459" target="_blank" >10.1111/cei.12459</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Low ficolin-2 levels in common variable immunodeficiency patients with bronchiectasis

  • Original language description

    Common variable immunodeficiency (CVID) encompasses a heterogeneous group of antibody deficiencies characterized by susceptibility to recurrent infections and sequelae, including bronchiectasis. We investigated the relevance of the lectin complement pathway in CVID patients by analysing ficolin-2 and ficolin-3 serum levels and genotyping single nucleotide polymorphisms (SNPs) in the FCN2 and FCN3 genes. Our results show that ficolin-2 levels in CVID patients are significantly lower (P&lt;00001) than incontrols. The lowest ficolin-2 levels are found in CVID patients with bronchiectasis (P=00004) and autoimmunity (P=004). Although serum levels of ficolin-3 were similar in CVID patients and controls, CVID patients with bronchiectasis again showed lower levels when compared to controls (P=00001). Analysis of single nucleotide polymorphisms in the FCN2 gene confirmed known influences on ficolin-2 serum levels, but did not support a genetic basis for the observed ficolin-2 deficiency in CVI

  • Czech name

    —

  • Czech description

    —

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EC - Immunology

  • OECD FORD branch

    —

Result continuities

  • Project

    <a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Clinical and Experimental Immunology

  • ISSN

    0009-9104

  • e-ISSN

    —

  • Volume of the periodical

    179

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    256-264

  • UT code for WoS article

    000347233800012

  • EID of the result in the Scopus database

    —

Similar results(10)

Mannose-binding lectin gene polymorphic variants predispose to the development of bronchopulmonary complications but have no influence on other clinical and laboratory symptoms or signs of common variable immunodeficiencyAssociation of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiencyAnalysis of zinc, iron, and copper levels in patients with common variable immunodeficiency.