Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072942" target="_blank" >RIV/00159816:_____/20:00072942 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/20:00116219
Result on the web
<a href="https://www.j-stroke.org/upload/pdf/jos-2019-01648.pdf" target="_blank" >https://www.j-stroke.org/upload/pdf/jos-2019-01648.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5853/jos.2019.01648" target="_blank" >10.5853/jos.2019.01648</a>
Alternative languages
Result language
angličtina
Original language name
Timing of Recanalization and Functional Recovery in Acute Ischemic Stroke
Original language description
Background and Purpose Although onset-to-treatment time is associated with early clinical recovery in acute ischemic stroke (AIS) patients treated with intravenous tissue plasminogen activator (tPA), the effect of the timing of tPA-induced recanalization on functional outcomes remains debatable. Methods We conducted a multicenter, prospective observational cohort study to determine whether early (within 1-hour from tPA-bolus) complete or partial recanalization assessed during 2-hour real-time transcranial Doppler monitoring is associated with improved outcomes in patients with proximal occlusions. Outcome events included dramatic clinical recovery (DCR) within 2 and 24-hours from tPA-bolus, 3-month mortality, favorable functional outcome (FF0) and functional independence (FI) defined as modified Rankin Scale (mRS) scores of 0-1 and 0-2 respectively. Results We enrolled 480 AIS patients (mean age 66 +/- 15 years, 60% men, baseline National Institutes of Health Stroke Scale score 15). Patients with early recanalization (53% vs 10%) had significantly (P<0.001) higher rates of DCR at 2-hour (54% vs. 10%) and 24-hour (63% vs. 22%), 3-month FFO (67% vs. 28 %) and F1 (81% vs. 39%). Three-month mortality rates (6% vs. 17%) and distribution of 3-month mRS scores were significantly lower in the early recanalization group. After adjusting for potential confounders, early recanalization was independently associated with higher odds of 3-month FFO (odds ratio [011], 6.19; 95% confidence interval [CI], 3.88 to 9.88) and lower likelihood of 3-month mortality (OR, 0.34; 95% CI, 0.17 to 0.67). Onset to treatment time correlated to the elapsed time between tPA-bolus and recanalization (unstandardized linear regression coefficient, 0.13; 95% CI, 0.06 to 0.19). Conclusions Earlier tPA treatment after stroke onset is associated with faster tPA-induced recanalization. Earlier onset-to-recanalization time results in improved functional recovery and survival in AIS patients with proximal intracranial occlusions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30210 - Clinical neurology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Stroke
ISSN
2287-6391
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
1
Country of publishing house
KR - KOREA, REPUBLIC OF
Number of pages
20
Pages from-to
130-"+"
UT code for WoS article
000512366600011
EID of the result in the Scopus database
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