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Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F20%3A00072951" target="_blank" >RIV/00159816:_____/20:00072951 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/20:00115426

  • Result on the web

    <a href="https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.4VMA0318-138R" target="_blank" >https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.4VMA0318-138R</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1002/JLB.4VMA0318-138R" target="_blank" >10.1002/JLB.4VMA0318-138R</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes

  • Original language description

    Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested the hypothesis that CN inhibition interferes with antifungal immune defenses mediated by monocytes. We showed that NFAT is expressed by human monocytes, and is activated by exposure to fungal ligands. We confirmed that NFAT translocation potently activated target gene transcription using a human monocytic reporter cell line. Inhibition of CN-NFAT by cyclosporine A significantly reduced monocyte production of TNF-alpha, IL-10, and MCP-1 proteins in response to pattern recognition receptor ligands as well as to Aspergillus fumigatus conidia. Moreover, we revealed that human monocytes express the antifungal protein pentraxin-3 under control of NFAT. In conclusion, clinical CN inhibitors have the potential to interfere with the novel NFAT-dependent pentraxin-3 pathway as well as antifungal cytokine production in human monocytes, thereby impeding monocyte-mediated defenses against fungal infection in immune-suppressed patients.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10601 - Cell biology

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of leukocyte biology

  • ISSN

    0741-5400

  • e-ISSN

  • Volume of the periodical

    107

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    12

  • Pages from-to

    497-508

  • UT code for WoS article

    000515440500012

  • EID of the result in the Scopus database