MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00074082" target="_blank" >RIV/00159816:_____/21:00074082 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/21:00120135

Result on the web

<a href="https://www.thno.org/v11p6058.htm" target="_blank" >https://www.thno.org/v11p6058.htm</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.7150/thno.56327" target="_blank" >10.7150/thno.56327</a>

Result language

angličtina

Original language name

MicroRNAs as theranostic markers in cardiac allograft transplantation: from murine models to clinical practice

Original language description

Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation remains one of the last options for patients with terminal refractory heart failure. Besides the infectious or oncological complications, the prognosis of patients after heart transplantation is affected by acute cellular or antibody-mediated rejection and allograft vasculopathy development. Current monitoring of both conditions requires the performance of invasive procedures (endomyocardial biopsy sampling and coronary angiography or optical coherence tomography, respectively) that are costly, time-demanding, and non-comfortable for the patient. Within this narrative review, we focus on the potential pathophysiological and clinical roles of microRNAs (miRNAs, miRs) in the field of cardiac allograft transplantation. Firstly, we provide a general introduction about the status of cardiac allograft function monitoring and the discovery of miRNAs as post-transcriptional regulators of gene expression and clinically relevant biomarkers found in the extracellular fluid. After this general introduction, information from animal and human studies are summarized to underline the importance of miRNAs both in the pathophysiology of the rejection process, the possibility of its modulation by altering miRNAs levels, and last but not least, about the use of miRNAs in the clinical practice to diagnose or predict the rejection occurrence.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30100 - Basic medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Theranostics

ISSN

1838-7640

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

12

Country of publishing house

AU - AUSTRALIA

Number of pages

16

Pages from-to

6058-6073

UT code for WoS article

000642591000004

EID of the result in the Scopus database

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