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Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075129" target="_blank" >RIV/00159816:_____/21:00075129 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/21:00120174

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/pii/S1873506121002245?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506121002245?via%3Dihub</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.scr.2021.102378" target="_blank" >10.1016/j.scr.2021.102378</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Generation of three human iPSC lines from patients with a spontaneous late-onset Alzheimer's disease and three sex- and age-matched healthy controls

  • Original language description

    Human induced pluripotent stem cell (iPSC) lines were generated from patients with spontaneous late-onset Alzheimer&apos;s disease (AD) and three healthy control individuals. Peripheral blood mononuclear cells were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer&apos;s disease in vitro.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    20601 - Medical engineering

Result continuities

  • Project

    <a href="/en/project/NV19-08-00472" target="_blank" >NV19-08-00472: Clinically relevant biochemical, immunological and cellular biomarkers of Alzheimer's disease and aging</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2021

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Stem Cell Research

  • ISSN

    1873-5061

  • e-ISSN

  • Volume of the periodical

    53

  • Issue of the periodical within the volume

    May

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

  • UT code for WoS article

    000656247000002

  • EID of the result in the Scopus database