Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer's Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F24%3A00081789" target="_blank" >RIV/00159816:_____/24:00081789 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00135580
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1873506123002593" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506123002593</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scr.2023.103273" target="_blank" >10.1016/j.scr.2023.103273</a>
Alternative languages
Result language
angličtina
Original language name
Generation of the Human iPSC Line from Spontaneous Late-Onset Alzheimer's Disease Patient with ApoE3/3 Genotype and Sex-, Age-, and ApoE-Matched Healthy Control
Original language description
Human induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) isolated from a patient diagnosed with spontaneous late -onset Alzheimer's disease (AD) carrying ApoE3/3 gene and one age-, sex-, and ApoE-matched healthy control. Reprogramming was done using a commercially available Epi5 Reprogramming Kit containing OCT4, SOX2, KLF4, LIN28, and L-MYC as reprogramming factors. The pluripotency of the iPSC lines was verified by the expression of pluripotency markers and by their capacity to differentiate into all three embryonic germ layers in vitro. These newly established iPSC lines offer a valuable platform for in vitro modeling of AD.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10600 - Biological sciences
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Research
ISSN
1873-5061
e-ISSN
1876-7753
Volume of the periodical
74
Issue of the periodical within the volume
FEB 2024
Country of publishing house
US - UNITED STATES
Number of pages
4
Pages from-to
103273
UT code for WoS article
001160676800001
EID of the result in the Scopus database
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