Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075135" target="_blank" >RIV/00159816:_____/21:00075135 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/21:00120161
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1873506121002257?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1873506121002257?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.scr.2021.102379" target="_blank" >10.1016/j.scr.2021.102379</a>

Result language
angličtina
Original language name
Generation of six human iPSC lines from patients with a familial Alzheimer's disease (n=3) and sex- and age-matched healthy controls (n=3)
Original language description
Human induced pluripotent stem cell (iPSC) lines were generated from primary human fibroblasts isolated from three patients with a familial form of Alzheimer's disease (AD) and three healthy control individuals. Two AD-iPSC lines carry a PSEN1 mutation A246E; the third cell line carries a PSEN2 mutation N141I. The fibroblasts were reprogrammed with Yamanaka factors (OSKM) using a commercially available Epi5 Reprogramming Kit. The pluripotency of iPSCs was confirmed by the expression of pluripotency factors and by their ability to differentiate to all three germ layers in vitro. Newly derived cell lines can be used to model Alzheimer's disease in vitro.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
20601 - Medical engineering

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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