Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F21%3A00075149" target="_blank" >RIV/00159816:_____/21:00075149 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S1064748120303754?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1064748120303754?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jagp.2020.06.006" target="_blank" >10.1016/j.jagp.2020.06.006</a>

Result language

angličtina

Original language name

Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Original language description

Objective: The authors conducted a prospective cohort study to examine the risk of incident mild cognitive impairment (MCI) as predicted by baseline neuropsychiatric symptoms (NPS) and brain regional glucose metabolic dysfunction. Methods: About 1,363 cognitively unimpaired individuals (52.8% males) aged &gt;= 50 years were followed for a median of 4.8 years to the outcome of incident MCI. NPS were assessed using Beck Depression and Anxiety Inventories and Neuropsychiatric Inventory Questionnaire. Glucose hypometabolism was measured by fluorodeoxyglucose positron emission tomography and defined as standardized uptake value ratio &lt;= 1.47 in regions typically affected in Alzheimer disease. Cox proportional hazards models were adjusted for age, sex, education, and APOE epsilon 4 status. Results: Participants with regional glucose hypometabolism and depression (Beck Depression Inventory-II &gt;= 13) had a more than threefold increased risk of incident MCI (hazard ratio [95% confidence interval], 3.66 [1.75, 7.65], p &lt;0.001, chi(2) = 11.83, degree of freedom [df] =1) as compared to the reference group (normal regional glucose metabolism and no depression), and the risk was also significantly elevated (7.21 13.54, 14.7], p &lt;0.001, f = 29.68, df =1) for participants with glucose hypometabolism and anxiety (Beck Anxiety Inventory &gt;= 10). Having glucose hypometabolism and &gt;= 1 NPS (3. 74 12.40, 5.82], p &lt;0.001, chi(2) = 34. 13, df =1) or &gt;= 2 NPS (3.89 12.20, 686], p &lt;0.001, chi(2) = 21.92, df = 1) increased the risk of incident MCI by more than three times, and having &gt;= 3 NPS increased the risk by more than four times (4.12 12.03, 8.3 7], p &lt;0.001, chi(2) = 15.39, df =1). Conclusion: Combined presence of NPS with regional glucose hypometabolism is associated with an increased risk of incident MCI, with fluorodeoxyglucose positron emission tomography appearing to be a stronger driving force of cognitive decline than NPS.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30227 - Geriatrics and gerontology

Project

<a href="/en/project/LQ1605" target="_blank" >LQ1605: Translational Medicine</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2021

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

American Journal of Geriatric Psychiatry

ISSN

1064-7481

e-ISSN

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Volume of the periodical

29

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

13

Pages from-to

179-191

UT code for WoS article

000632165600002

EID of the result in the Scopus database

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