Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077668" target="_blank" >RIV/00159816:_____/22:00077668 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/22:00013415 RIV/00216224:14110/22:00126339 RIV/00216208:11310/22:10454842
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2022.899368/full#h8" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2022.899368/full#h8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2022.899368" target="_blank" >10.3389/fcell.2022.899368</a>

Result language
angličtina
Original language name
Lung Organoids-The Ultimate Tool to Dissect Pulmonary Diseases?
Original language description
Organoids are complex multicellular three-dimensional (3D) in vitro models that are designed to allow accurate studies of the molecular processes and pathologies of human organs. Organoids can be derived from a variety of cell types, such as human primary progenitor cells, pluripotent stem cells, or tumor-derived cells and can be co-cultured with immune or microbial cells to further mimic the tissue niche. Here, we focus on the development of 3D lung organoids and their use as disease models and drug screening tools. We introduce the various experimental approaches used to model complex human diseases and analyze their advantages and disadvantages. We also discuss validation of the organoids and their physiological relevance to the study of lung diseases. Furthermore, we summarize the current use of lung organoids as models of host-pathogen interactions and human lung diseases such as cystic fibrosis, chronic obstructive pulmonary disease, or SARS-CoV-2 infection. Moreover, we discuss the use of lung organoids derived from tumor cells as lung cancer models and their application in personalized cancer medicine research. Finally, we outline the future of research in the field of human induced pluripotent stem cell-derived organoids.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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