Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F19%3A00520812" target="_blank" >RIV/68378041:_____/19:00520812 - isvavai.cz</a>
Result on the web
<a href="https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3089" target="_blank" >https://stemcellsjournals.onlinelibrary.wiley.com/doi/full/10.1002/stem.3089</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/stem.3089" target="_blank" >10.1002/stem.3089</a>
Alternative languages
Result language
angličtina
Original language name
Deciphering retinal diseases through the generation of three dimensional stem cell-derived organoids: Concise Review
Original language description
Three-dimensional (3D) retinal organoids, in vitro tissue structures derived from self-organizing cultures of differentiating human embryonic stem cells or induced pluripotent stem cells, could recapitulate some aspects of the cytoarchitectural structure and function of the retina in vivo. 3D retinal organoids display huge potential for the investigation of the pathogenesis of monogenic hereditary eye diseases that are related to the malfunction or degeneration of photoreceptors or retinal ganglion cells by providing an effective in vitro tool with multiple applications. In combination with recent genome editing tools, 3D retinal organoids could also represent a reliable and renewable source of transplantable cells for personalized therapies. In this review, we describe the recent advances in human pluripotent stem cells-derived retinal organoids, determination of their histoarchitecture, complexity, and maturity. We also discuss their application as a means to decipher the pathogenesis of retinal diseases, as well as the main drawbacks and challenges.
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
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OECD FORD branch
30105 - Physiology (including cytology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cells
ISSN
1066-5099
e-ISSN
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Volume of the periodical
37
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
1496-1504
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-85074635107