Mitochondrial behavior when things go wrong in the axon
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00077728" target="_blank" >RIV/00159816:_____/22:00077728 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fncel.2022.959598/full#h8" target="_blank" >https://www.frontiersin.org/articles/10.3389/fncel.2022.959598/full#h8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fncel.2022.959598" target="_blank" >10.3389/fncel.2022.959598</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial behavior when things go wrong in the axon
Original language description
Axonal homeostasis is maintained by processes that include cytoskeletal regulation, cargo transport, synaptic activity, ionic balance, and energy supply. Several of these processes involve mitochondria to varying degrees. As a transportable powerplant, the mitochondria deliver ATP and Ca2+-buffering capabilities and require fusion/fission to maintain proper functioning. Taking into consideration the long distances that need to be covered by mitochondria in the axons, their transport, distribution, fusion/fission, and health are of cardinal importance. However, axonal homeostasis is disrupted in several disorders of the nervous system, or by traumatic brain injury (TBI), where the external insult is translated into physical forces that damage nervous tissue including axons. The degree of damage varies and can disconnect the axon into two segments and/or generate axonal swellings in addition to cytoskeletal changes, membrane leakage, and changes in ionic composition. Cytoskeletal changes and increased intra-axonal Ca2+ levels are the main factors that challenge mitochondrial homeostasis. On the other hand, a proper function and distribution of mitochondria can determine the recovery or regeneration of the axonal physiological state. Here, we discuss the current knowledge regarding mitochondrial transport, fusion/fission, and Ca2+ regulation under axonal physiological or pathological conditions.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
FRONTIERS IN CELLULAR NEUROSCIENCE
ISSN
1662-5102
e-ISSN
1662-5102
Volume of the periodical
16
Issue of the periodical within the volume
August
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
nestrankovano
UT code for WoS article
000891364900001
EID of the result in the Scopus database
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