Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00533843" target="_blank" >RIV/61388955:_____/20:00533843 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11104/0312095" target="_blank" >http://hdl.handle.net/11104/0312095</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/membranes10100299" target="_blank" >10.3390/membranes10100299</a>
Alternative languages
Result language
angličtina
Original language name
Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins
Original language description
Mitochondria represent the fundamental system for cellular energy metabolism, by not only supplying energy in the form of ATP, but also by affecting physiology and cell death via the regulation of calcium homeostasis and the activity of Bcl‐2 proteins. A lot of research has recently been devoted to understanding the interplay between Bcl‐2 proteins, the regulation of these interactions within the cell, and how these interactions lead to the changes in calcium homeostasis. However, the role of Bcl‐2 proteins in the mediation of mitochondrial calcium homeostasis, and therefore the induction of cell death pathways, remain underestimated and are still not well understood. In this review, we first summarize our knowledge about calcium transport systems in mitochondria, which, when miss‐regulated, can induce necrosis. We continue by reviewing and analyzing the functions of Bcl‐2 proteins in apoptosis. Finally, we link these two regulatory mechanisms together, exploring the interactions between the mitochondrial Ca2+ transport systems and Bcl‐2 proteins, both capable of inducing cell death, with the potential to determine the cell death pathway—either the apoptotic or the necrotic one.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10403 - Physical chemistry
Result continuities
Project
<a href="/en/project/GA18-04871S" target="_blank" >GA18-04871S: Oxidative stress as an essential modulator of Bax apoptotic activity: molecular insights by single-molecule fluorescence</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Membranes
ISSN
2077-0375
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
10
Country of publishing house
CH - SWITZERLAND
Number of pages
32
Pages from-to
299
UT code for WoS article
000586146500001
EID of the result in the Scopus database
2-s2.0-85093943795