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Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00533843" target="_blank" >RIV/61388955:_____/20:00533843 - isvavai.cz</a>

  • Result on the web

    <a href="http://hdl.handle.net/11104/0312095" target="_blank" >http://hdl.handle.net/11104/0312095</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3390/membranes10100299" target="_blank" >10.3390/membranes10100299</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Regulation of cell death by mitochondrial transport systems of calcium and BCL‐2 proteins

  • Original language description

    Mitochondria represent the fundamental system for cellular energy metabolism, by not only supplying energy in the form of ATP, but also by affecting physiology and cell death via the regulation of calcium homeostasis and the activity of Bcl‐2 proteins. A lot of research has recently been devoted to understanding the interplay between Bcl‐2 proteins, the regulation of these interactions within the cell, and how these interactions lead to the changes in calcium homeostasis. However, the role of Bcl‐2 proteins in the mediation of mitochondrial calcium homeostasis, and therefore the induction of cell death pathways, remain underestimated and are still not well understood. In this review, we first summarize our knowledge about calcium transport systems in mitochondria, which, when miss‐regulated, can induce necrosis. We continue by reviewing and analyzing the functions of Bcl‐2 proteins in apoptosis. Finally, we link these two regulatory mechanisms together, exploring the interactions between the mitochondrial Ca2+ transport systems and Bcl‐2 proteins, both capable of inducing cell death, with the potential to determine the cell death pathway—either the apoptotic or the necrotic one.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10403 - Physical chemistry

Result continuities

  • Project

    <a href="/en/project/GA18-04871S" target="_blank" >GA18-04871S: Oxidative stress as an essential modulator of Bax apoptotic activity: molecular insights by single-molecule fluorescence</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Membranes

  • ISSN

    2077-0375

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    10

  • Country of publishing house

    CH - SWITZERLAND

  • Number of pages

    32

  • Pages from-to

    299

  • UT code for WoS article

    000586146500001

  • EID of the result in the Scopus database

    2-s2.0-85093943795