Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F09%3A00028421" target="_blank" >RIV/00216224:14310/09:00028421 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/09:5137 RIV/68081707:_____/09:00345303
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Heavy metals induce phosphorylation of the Bcl-2 protein by Jun N-terminal kinase
Original language description
The Bcl-2 protein is one of the key components of biochemical pathways controling programmed cell death. Function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significantly associated with cell cycle arrest in the G2/M phase of the cell cycle, and with cell death caused by defects of microtubule dynamics. This study shows that phosphorylation of Bcl-2 can be induced by heavy metals due to activation of the Jun N-terminal kinase pathway that is not linked to the G2/M cell cycle arrest. Furthermore, we show that hyperphosphorylated Bcl-2 protein is a more potent inhibitor of zinc-induced cell death than its hypophosphorylated mutant form. These data suggest that regulation of theBcl-2 protein function by phosphorylation is an important part of cell response to stress.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2009
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biological Chemistry
ISSN
1431-6730
e-ISSN
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Volume of the periodical
390/2009
Issue of the periodical within the volume
12
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
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UT code for WoS article
000263247800008
EID of the result in the Scopus database
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