The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00077968" target="_blank" >RIV/00159816:_____/23:00077968 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/23:00130703 RIV/65269705:_____/23:00077968

Result on the web

<a href="https://openres.ersjournals.com/content/erjor/9/2/00421-2022.full.pdf" target="_blank" >https://openres.ersjournals.com/content/erjor/9/2/00421-2022.full.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00421-2022" target="_blank" >10.1183/23120541.00421-2022</a>

Result language

angličtina

Original language name

The risk of post-operative pulmonary complications in lung resection candidates with normal forced expiratory volume in 1 s and diffusing capacity of the lung for carbon monoxide: a prospective multicentre study

Original language description

Introduction According to the guidelines for preoperative assessment of lung resection candidates, patients with normal forced expiratory volume in 1 s (FEV1) and diffusing capacity of the lung for carbon monoxide (DLCO) are at low risk for post-operative pulmonary complications (PPC). However, PPC affect hospital length of stay and related healthcare costs. We aimed to assess risk of PPC for lung resection candidates with normal FEV1 and D-LCO (&gt;80% predicted) and identify factors associated with PPC. Methods 398 patients were prospectively studied at two centres between 2017 and 2021. PPC were recorded from the first 30 post-operative days. Subgroups of patients with and without PPC were compared and factors with significant difference were analysed by uni- and multivariate logistic regression. Results 188 subjects had normal FEV1 and D-LCO. Of these, 17 patients (9%) developed PPC. Patients with PPC had significantly lower pressure of end-tidal carbon dioxide (P-ETCO2) at rest (27.7 versus 29.9; p=0.033) and higher ventilatory efficiency (V&apos;(E)/V&apos;(CO2)) slope (31.1 versus 28; p=0.016) compared to those without PPC. Multivariate models showed association between resting P-ETCO2 (OR 0.872; p=0.035) and V&apos;(E)/V&apos;(CO2) slope (OR 1.116; p=0.03) and PPC. In both models, thoracotomy was strongly associated with PPC (OR 6.419; p=0.005 and OR 5.884; p=0.007, respectively). Peak oxygen consumption failed to predict PPC ( p=0.917). Conclusions Resting P-ETCO2 adds incremental information for risk prediction of PPC in patients with normal FEV1 and D-LCO. We propose resting P-ETCO2 be an additional parameter to FEV1 and D-LCO for preoperative risk stratification.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30203 - Respiratory systems

Project

<a href="/en/project/NU21-06-00086" target="_blank" >NU21-06-00086: High intensity respiratory muscle training as a pre-habilitation in lung surgery candidates</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2023

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ERJ Open Research

ISSN

2312-0541

e-ISSN

2312-0541

Volume of the periodical

9

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

00421-2022

UT code for WoS article

000947843200012

EID of the result in the Scopus database

2-s2.0-85150225230