Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F22%3A00076200" target="_blank" >RIV/00159816:_____/22:00076200 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/22:00076200 RIV/00216224:14110/22:00127257

Result on the web

<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0272984</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0272984" target="_blank" >10.1371/journal.pone.0272984</a>

Result language

angličtina

Original language name

Ventilatory efficiency is superior to peak oxygen uptake for prediction of lung resection cardiovascular complications

Original language description

IntroductionVentilatory efficiency (V-E/VCO2 slope) has been shown superior to peak oxygen consumption (VO2) for prediction of post-operative pulmonary complications in patients undergoing thoracotomy. V-E/VCO2 slope is determined by ventilatory drive and ventilation/perfusion mismatch whereas VO2 is related to cardiac output and arteriovenous oxygen difference. We hypothesized pre-operative VO2 predicts post-operative cardiovascular complications in patients undergoing lung resection. MethodsLung resection candidates from a published study were evaluated by post-hoc analysis. All of the patients underwent preoperative cardiopulmonary exercise testing. Post-operative cardiovascular complications were assessed during the first 30 post-operative days or hospital stay. One-way analysis of variance or the Kruskal-Wallis test, and multivariate logistic regression were used for statistical analysis and data summarized as median (IQR). ResultsOf 353 subjects, 30 (9%) developed pulmonary complications only (excluded from further analysis), while 78 subjects (22%) developed cardiovascular complications and were divided into two groups for analysis: cardiovascular only (n = 49) and cardiovascular with pulmonary complications (n = 29). Compared to patients without complications (n = 245), peak VO2 was significantly lower in the cardiovascular with pulmonary complications group [19.9 ml/kg/min (16.5-25) vs. 16.3 ml/kg/min (15-20.3); P&lt;0.01] but not in the cardiovascular only complications group [19.9 ml/kg/min (16.5-25) vs 19.0 ml/kg/min (16-23.1); P = 0.18]. In contrast, V-E/VCO2 slope was significantly higher in both cardiovascular only [29 (25-33) vs. 31 (27-37); P = 0.05] and cardiovascular with pulmonary complication groups [29 (25-33) vs. 37 (34-42); P&lt;0.01)]. Logistic regression analysis showed V-E/VCO2 slope [OR = 1.06; 95%CI (1.01-1.11); P = 0.01; AUC = 0.74], but not peak VO2 to be independently associated with post-operative cardiovascular complications. ConclusionV(E)/VCO2 slope is superior to peak VO2 for prediction of post-operative cardiovascular complications in lung resection candidates.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10700 - Other natural sciences

Project

<a href="/en/project/NU21-06-00086" target="_blank" >NU21-06-00086: High intensity respiratory muscle training as a pre-habilitation in lung surgery candidates</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

1932-6203

Volume of the periodical

17

Issue of the periodical within the volume

8

Country of publishing house

US - UNITED STATES

Number of pages

12

Pages from-to

nestrankovano

UT code for WoS article

000944132200052

EID of the result in the Scopus database

2-s2.0-85135950162