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Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079643" target="_blank" >RIV/00159816:_____/23:00079643 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216224:14110/23:00133225

  • Result on the web

    <a href="https://www.sciencedirect.com/science/article/abs/pii/S1896112623000457" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1896112623000457</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.advms.2023.10.005" target="_blank" >10.1016/j.advms.2023.10.005</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy

  • Original language description

    Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important modulators of cellular proliferation and differentiation, and are strongly associated with the molecular orchestration of carcinogenesis. The expression and/or activity of HSPs in cancer cells is generally abnormally high and is associated with increased metastatic potential and activity of cancer stem cells, more pronounced angiogenesis, downregulated apoptosis, and the resistance to anticancer therapy in many patients. Based on the mentioned reasons, HSPs have strong potential as valid diagnostic, prognostic, and therapeutic biomarkers in clinical oncology. In addition, numerous papers describe the role of HSPs as chaperones in the regulation of immune responses inside and outside the cell. Importantly, highly expressed/activated HSPs may be inhibited via immunotherapeutic targets in various types of cancers. The aim of this work is to provide a comprehensive overview of the relationship between HSPs and the tumor cell with the intention of highlighting the potential use of HSPs in personalized cancer management.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30100 - Basic medicine

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Advances in medical sciences

  • ISSN

    1896-1126

  • e-ISSN

    1898-4002

  • Volume of the periodical

    68

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    464-473

  • UT code for WoS article

    001110341700001

  • EID of the result in the Scopus database