Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00159816%3A_____%2F23%3A00079643" target="_blank" >RIV/00159816:_____/23:00079643 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/23:00133225
Result on the web
<a href="https://www.sciencedirect.com/science/article/abs/pii/S1896112623000457" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S1896112623000457</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.advms.2023.10.005" target="_blank" >10.1016/j.advms.2023.10.005</a>
Alternative languages
Result language
angličtina
Original language name
Heat shock proteins in cancer - Known but always being rediscovered: Their perspectives in cancer immunotherapy
Original language description
Heat shock proteins (HSPs) represent cellular chaperones that are classified into several families, including HSP27, HSP40, HSP60, HSP70, and HSP90. The role of HSPs in the cell includes the facilitation of protein folding and maintaining protein structure. Both processes play crucial roles during stress conditions in the cell such as heat shock, degradation, and hypoxia. Moreover, HSPs are important modulators of cellular proliferation and differentiation, and are strongly associated with the molecular orchestration of carcinogenesis. The expression and/or activity of HSPs in cancer cells is generally abnormally high and is associated with increased metastatic potential and activity of cancer stem cells, more pronounced angiogenesis, downregulated apoptosis, and the resistance to anticancer therapy in many patients. Based on the mentioned reasons, HSPs have strong potential as valid diagnostic, prognostic, and therapeutic biomarkers in clinical oncology. In addition, numerous papers describe the role of HSPs as chaperones in the regulation of immune responses inside and outside the cell. Importantly, highly expressed/activated HSPs may be inhibited via immunotherapeutic targets in various types of cancers. The aim of this work is to provide a comprehensive overview of the relationship between HSPs and the tumor cell with the intention of highlighting the potential use of HSPs in personalized cancer management.
Czech name
—
Czech description
—
Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30100 - Basic medicine
Result continuities
Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Advances in medical sciences
ISSN
1896-1126
e-ISSN
1898-4002
Volume of the periodical
68
Issue of the periodical within the volume
2
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
464-473
UT code for WoS article
001110341700001
EID of the result in the Scopus database
—