Heat Shock Protein Network: the Mode of Action, the Role in Protein Folding and Human Pathologies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388971%3A_____%2F24%3A00603830" target="_blank" >RIV/61388971:_____/24:00603830 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10494298
Result on the web
<a href="https://foliabiologica.lf1.cuni.cz/70/3/0152/" target="_blank" >https://foliabiologica.lf1.cuni.cz/70/3/0152/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.14712/fb2024070030152" target="_blank" >10.14712/fb2024070030152</a>
Alternative languages
Result language
angličtina
Original language name
Heat Shock Protein Network: the Mode of Action, the Role in Protein Folding and Human Pathologies
Original language description
Protein folding is an extremely complicated process, which has been extensively tackled during the last decades. In vivo, a certain molecular machinery is responsible for assisting the correct folding of proteins and maintaining protein homeostasis: the members of this machinery are the heat shock proteins (HSPs), which belong among molecular chaperones. Mutations in HSPs are associated with several inherited diseases, and members of this group were also proved to be involved in neurodegenerative pathologies (e.g., Alzheimer and Parkinson diseases), cancer, viral infections, and antibiotic resistance of bacteria. Therefore, it is critical to understand the principles of HSP functioning and their exact role in human physiology and pathology. This review attempts to briefly describe the main chaperone families and the interplay between individual chaperones, as well as their general and specific functions in the context of cell physiology and human diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10606 - Microbiology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Folia Biologica
ISSN
0015-5500
e-ISSN
0015-5500
Volume of the periodical
70
Issue of the periodical within the volume
3
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
14
Pages from-to
152-165
UT code for WoS article
001372840400002
EID of the result in the Scopus database
2-s2.0-85212021960