The many roles of molecular chaperones and co-chaperones in tumour biology

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000302" target="_blank" >RIV/00209805:_____/12:#0000302 - isvavai.cz</a>

Result on the web

<a href="http://www.linkos.cz/files/klinicka-onkologie/174/4127.pdf" target="_blank" >http://www.linkos.cz/files/klinicka-onkologie/174/4127.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The many roles of molecular chaperones and co-chaperones in tumour biology

Original language description

Molecular chaperones (heat-shock proteins, Hsps) are proteins that maintain intracellular homeostasis through folding and stabilisation of the conformation of other proteins. Molecular chaperones are critical for survival of cells that undergo cellular stress due to their ability to guard the proteome against misfolded proteins and aggregation. In addition to their canonical role in basic cellular homeostasis and protection against external stress, several molecular chaperones play a fundamental role inmalignant cell transformation. The level of molecular chaperones is increased in many solid tumours and haematological malignancies. The increased activity of Hsps in cancer cells reflects the ability of chaperones to compensate for stress caused by hypoxia, increased protein turnover and the presence of numerous mutated and potentially unstable proteins. In addition, chaperones allow tumour cells to tolerate genetic alterations by stabilising tertiary structure of mutated unstable prot

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Klinická onkologie

ISSN

0862-495X

e-ISSN

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Volume of the periodical

25

Issue of the periodical within the volume

supplementum 2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

5

Pages from-to

"2S45"-"2S49"

UT code for WoS article

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EID of the result in the Scopus database

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